› 8x55

Electron Microscopy
3.75Å resolution

BA.2.86 Spike Trimer with T356K mutation (3 RBD down)

Released:
DOI: 10.2210/pdb8x55/pdb
PDB entry 8x55 coloured by chain, front view.
PDB entry 8x55 coloured by chain, side view.
PDB entry 8x55 coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev 11 nwae206 (2024)
PMID: 39071099
Related structures: EMD-38063

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1206 amino acids
Theoretical weight: 134.07 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-16, 17-1208; Coverage: 94%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 30 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.75Å
Relevant EMDB volumes: EMD-38063
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Subsequent Waves of Convergent Evolution in SARS-CoV-2 Genes and Proteins.
Focosi et al. (2024)
2 other articles