› 8x84

Electron Microscopy
3.1Å resolution

The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster in complex with fructose and calcium

Released:
DOI: 10.2210/pdb8x84/pdb
PDB entry 8x84 coloured by chain, front view.
PDB entry 8x84 coloured by chain, side view.
PDB entry 8x84 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural basis for sugar perception by Drosophila gustatory receptors.
Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, Guo J
Science eadj2609 (2024)
PMID: 38305684
Related structures: EMD-38135

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239746 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gustatory receptor for sugar taste 43a Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 443 amino acids
Theoretical weight: 49.27 KDa
Source organism: Drosophila melanogaster
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9V4K2 (Residues: 1-427; Coverage: 100%)
Gene names: CG1712, GR43.1, Gr43a
Sequence domains: 7tm Chemosensory receptor

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand FRU 4 x FRU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-38135
Expression system: Homo sapiens

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