› 8xmm

Electron Microscopy
2.89Å resolution

Voltage-gated sodium channel Nav1.7 variant M9

Released:
DOI: 10.2210/pdb8xmm/pdb
PDB entry 8xmm coloured by chain, front view.
PDB entry 8xmm coloured by chain, side view.
PDB entry 8xmm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dissection of the structure-function relationship of Nav channels.
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
Proc Natl Acad Sci U S A 121 e2322899121 (2024)
PMID: 38381792
Related structures: EMD-38482

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-218316 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium channel protein type 9 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 2031 amino acids
Theoretical weight: 231.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15858 (Residues: 1-1988; Coverage: 100%)
Gene names: NENA, SCN9A
Sequence domains:
Sodium channel regulatory subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 230 amino acids
Theoretical weight: 26.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
6 bound ligands:
Ligand NAG 6 x NAG
Ligand CLR 1 x CLR
Ligand LPE 9 x LPE
Ligand 1PW 1 x 1PW
Ligand PCW 6 x PCW
Ligand P5S 1 x P5S
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-38482
Expression system: Homo sapiens

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