› 8xuy

Electron Microscopy
3.14Å resolution

Structure of SARS-CoV-2 BA.2.86 spike glycoprotein in complex with ACE2 (2-up state)

Released:
DOI: 10.2210/pdb8xuy/pdb
PDB entry 8xuy coloured by chain, front view.
PDB entry 8xuy coloured by chain, side view.
PDB entry 8xuy coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1.
Yajima H, Anraku Y, Kaku Y, Kimura KT, Plianchaisuk A, Okumura K, Nakada-Nakura Y, Atarashi Y, Hemmi T, Kuroda D, Takahashi Y, Kita S, Sasaki J, Sumita H, Ito J, Maenaka K, Sato K, Hashiguchi T
Nat Commun 15 8574 (2024)
PMID: 39375326
Related structures: EMD-38686

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144663 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1235 amino acids
Theoretical weight: 137.33 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 28-1210; Coverage: 94%)
Gene names: 2, S
Sequence domains:
Processed angiotensin-converting enzyme 2 Chains: D, O
Molecule details ›
Chains: D, O
Length: 608 amino acids
Theoretical weight: 70.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 19-617; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 38 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.14Å
Relevant EMDB volumes: EMD-38686
Expression system: Homo sapiens

Quick links