› 8xza

Electron Microscopy
4.07Å resolution

BA.2.86 Spike in complex with bovine ACE2 (Local refinement)

Released:
DOI: 10.2210/pdb8xza/pdb
PDB entry 8xza coloured by chain, front view.
PDB entry 8xza coloured by chain, side view.
PDB entry 8xza coloured by chain, top view.
Source organisms:
Entry authors: Yue C, Liu P
Related structures: EMD-38791

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-534692 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike glycoprotein Chain: B
Molecule details ›
Chain: B
Length: 1206 amino acids
Theoretical weight: 134.04 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-16, 17-1208; Coverage: 94%)
Gene names: 2, S
Sequence domains:
Angiotensin-converting enzyme Chain: A
Molecule details ›
Chain: A
Length: 804 amino acids
Theoretical weight: 93.2 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2HJI5 (Residues: 1-804; Coverage: 100%)
Gene name: ACE2
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 7 x NAG
Ligand ZN 1 x ZN
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.07Å
Relevant EMDB volumes: EMD-38791
Expression system: Homo sapiens

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