› 8zcl

X-ray diffraction
2.6Å resolution

Ambient Temperature Crystal Structure of Fc Fragment of Human IgG1 from Biosimilar VEGF-Trap

Released:
DOI: 10.2210/pdb8zcl/pdb
PDB entry 8zcl coloured by chain, front view.
PDB entry 8zcl coloured by chain, side view.
PDB entry 8zcl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Destan E, DeMirci H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-534181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Immunoglobulin gamma-1 heavy chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 208 amino acids
Theoretical weight: 23.63 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DOX5 (Residues: 239-446; Coverage: 46%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU PhotonJet-R
Spacegroup: P212121
Unit cell:
a: 50.47Å b: 79.99Å c: 143.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.179 0.236
Expression system: Cricetulus griseus

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