› 8zqo

Electron Microscopy
2.8Å resolution

Human high-affinity choline transporter CHT1 bound to HC-3 under NaCl condition, with sodium and chloride ions coordinated.

Released:
DOI: 10.2210/pdb8zqo/pdb
PDB entry 8zqo coloured by chain, front view.
PDB entry 8zqo coloured by chain, side view.
PDB entry 8zqo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ion coupling and inhibitory mechanisms of the human presynaptic high-affinity choline transporter CHT1.
Qiu Y, Gao Y, Bai Q, Zhao Y
Structure (2024)
PMID: 39657660
Related structures: EMD-60386

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275345 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
High affinity choline transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 580 amino acids
Theoretical weight: 63.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZV3 (Residues: 1-580; Coverage: 100%)
Gene names: CHT1, SLC5A7
Sequence domains: Sodium:solute symporter family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
3 bound ligands:
Ligand NA 2 x NA
Ligand HC6 1 x HC6
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-60386
Expression system: Homo sapiens

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