› 8a17

X-ray diffraction
3.09Å resolution

Human PTPRM domains FN3-4, in spacegroup P3221

Released:
DOI: 10.2210/pdb8a17/pdb
PDB entry 8a17 coloured by chain, front view.
PDB entry 8a17 coloured by chain, side view.
PDB entry 8a17 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
Hay IM, Shamin M, Caroe ER, Mohammed ASA, Svergun DI, Jeffries CM, Graham SC, Sharpe HJ, Deane JE
OpenAccess logo J Biol Chem 299 102750 (2023)
PMID: 36436563

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Receptor-type tyrosine-protein phosphatase mu Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 258 amino acids
Theoretical weight: 28.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P28827 (Residues: 477-723; Coverage: 17%)
Gene names: PTPRL1, PTPRM
Sequence domains: Fibronectin type III domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3221
Unit cell:
a: 87.531Å b: 87.531Å c: 311.235Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.243 0.29
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Analysis of Receptor-Type Protein Tyrosine Phosphatase Extracellular Regions with Insights from AlphaFold.
El Badaoui et al. (2024)
1 other article

1 mention without citation

Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
Hay et al. (2023)