› 8a2k

X-ray diffraction
1.89Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 241 amino acids
Theoretical weight: 27.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 140-379; Coverage: 63%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand KXD 1 x KXD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21212
Unit cell:
a: 93.902Å b: 117.256Å c: 35.884Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.26
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Lipid-based nanoparticles as drug delivery systems for cancer immunotherapy.
Hao et al. (2023)
1 more

2 mentions without citation

The Many Ways to Deal with STING.
Coderch et al. (2023)
1 more