Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero hexadecamer (preferred)
PDBe Complex ID:
PDB-CPX-269365 (preferred)
Entry contents:
13 distinct polypeptide molecules
2 distinct DNA molecules
1 distinct RNA molecule
2 distinct DNA molecules
1 distinct RNA molecule
Macromolecules (16 distinct):
DNA-directed RNA polymerase subunit
Chain: A
Molecule details ›
Chain: A
Length: 1984 amino acids
Theoretical weight: 218.89 KDa
Source organism: Sus scrofa
UniProt:
Length: 1984 amino acids
Theoretical weight: 218.89 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
A0A7M4DUC2 (Residues: 1-1984; Coverage: 100%)
DNA-directed RNA polymerase subunit beta
Chain: B
Molecule details ›
Chain: B
Length: 1251 amino acids
Theoretical weight: 142.43 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 1251 amino acids
Theoretical weight: 142.43 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
I3LGP4 (Residues: 50-1300; Coverage: 96%)
Sequence domains:
DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein
Chain: C
Molecule details ›
Chain: C
Length: 275 amino acids
Theoretical weight: 31.44 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 275 amino acids
Theoretical weight: 31.44 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
I3LCH3 (Residues: 1-275; Coverage: 100%)
Sequence domains:
RNA polymerase Rpb4/RPC9 core domain-containing protein
Chain: D
Molecule details ›
Chain: D
Length: 142 amino acids
Theoretical weight: 16.33 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb4
Length: 142 amino acids
Theoretical weight: 16.33 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
A0A4X1VM56 (Residues: 1-142; Coverage: 100%)
Sequence domains: RNA polymerase Rpb4
DNA-directed RNA polymerase II subunit E
Chain: E
Molecule details ›
Chain: E
Length: 210 amino acids
Theoretical weight: 24.51 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 210 amino acids
Theoretical weight: 24.51 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
I3LSI7 (Residues: 1-210; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Chain: F
Molecule details ›
Chain: F
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb6
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
A0A4X1VEK9 (Residues: 1-127; Coverage: 100%)
Sequence domains: RNA polymerase Rpb6
DNA-directed RNA polymerase subunit
Chain: G
Molecule details ›
Chain: G
Length: 172 amino acids
Theoretical weight: 19.31 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 172 amino acids
Theoretical weight: 19.31 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
A0A4X1VKG7 (Residues: 1-172; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Chain: H
Molecule details ›
Chain: H
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb8
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
I3LCB2 (Residues: 1-150; Coverage: 100%)
Sequence domains: RNA polymerase Rpb8
DNA-directed RNA polymerase II subunit RPB9
Chain: I
Molecule details ›
Chain: I
Length: 125 amino acids
Theoretical weight: 14.54 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains:
Length: 125 amino acids
Theoretical weight: 14.54 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
P60899 (Residues: 1-125; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Chain: J
Molecule details ›
Chain: J
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerases N / 8 kDa subunit
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
A0A8W4F9W9 (Residues: 1-67; Coverage: 100%)
Sequence domains: RNA polymerases N / 8 kDa subunit
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein
Chain: K
Molecule details ›
Chain: K
Length: 117 amino acids
Theoretical weight: 13.31 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: RNA polymerase Rpb3/Rpb11 dimerisation domain
Length: 117 amino acids
Theoretical weight: 13.31 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
F1RKE4 (Residues: 1-117; Coverage: 100%)
Sequence domains: RNA polymerase Rpb3/Rpb11 dimerisation domain
RNA polymerase II, I and III subunit K
Chain: L
Molecule details ›
Chain: L
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Sus scrofa
UniProt:
Sequence domains: DNA directed RNA polymerase, 7 kDa subunit
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Sus scrofa
UniProt:
- Canonical:
A0A4X1TRS6 (Residues: 1-58; Coverage: 100%)
Sequence domains: DNA directed RNA polymerase, 7 kDa subunit
Transcription elongation factor A protein 1
Chain: U
Molecule details ›
Chain: U
Length: 304 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 304 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P23193 (Residues: 1-301; Coverage: 100%)
Sequence domains:
Non-template DNA
Chain: N
Molecule details ›
Chain: N
Length: 48 nucleotides
Theoretical weight: 14.93 KDa
Length: 48 nucleotides
Theoretical weight: 14.93 KDa
Template DNA
Chain: T
Molecule details ›
Chain: T
Length: 41 nucleotides
Theoretical weight: 12.46 KDa
Length: 41 nucleotides
Theoretical weight: 12.46 KDa
RNA
Chain: P
Molecule details ›
Chain: P
Length: 14 nucleotides
Theoretical weight: 4.51 KDa
Length: 14 nucleotides
Theoretical weight: 4.51 KDa