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Human RNA polymerase I

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: DNA-templated transcription
Cellular component: RNA polymerase I complex

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EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06870
Domain description: A49-like RNA polymerase I associated factor
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA49
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF06870 (A49-like RNA polymerase I associated factor) in DNA-directed RNA polymerase I subunit RPA49. Showing 1 copy in chain K [auth N].

PF08208
Domain description: DNA-directed RNA polymerase I subunit RPA34.5
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA34
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF08208 (DNA-directed RNA polymerase I subunit RPA34.5) in DNA-directed RNA polymerase I subunit RPA34. Showing 1 copy in chain L [auth M].

PF03604
Domain description: DNA directed RNA polymerase, 7 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF03604 (DNA directed RNA polymerase, 7 kDa subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC4. Showing 1 copy in chain J [auth L].

PF13656
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF13656 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerases I and III subunit RPAC2. Showing 1 copy in chain I [auth K].

PF01194
Domain description: RNA polymerases N / 8 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF01194 (RNA polymerases N / 8 kDa subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC5. Showing 1 copy in chain H [auth J].

PF01096
Domain description: Transcription factor S-II (TFIIS)
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA12
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF01096 (Transcription factor S-II (TFIIS)) in DNA-directed RNA polymerase I subunit RPA12. Showing 1 copy in chain G [auth I] (this domain is out of the observed residue ranges!).

PF03870
Domain description: RNA polymerase Rpb8
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF03870 (RNA polymerase Rpb8) in DNA-directed RNA polymerases I, II, and III subunit RPABC3. Showing 1 copy in chain F [auth H].

PF01192
Domain description: RNA polymerase Rpb6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF01192 (RNA polymerase Rpb6) in DNA-directed RNA polymerases I, II, and III subunit RPABC2. Showing 1 copy in chain E [auth F].

PF01191
Domain description: RNA polymerase Rpb5, C-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF01191 (RNA polymerase Rpb5, C-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain D [auth E].

PF03871
Domain description: RNA polymerase Rpb5, N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF03871 (RNA polymerase Rpb5, N-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain D [auth E].

PF01000
Domain description: RNA polymerase Rpb3/RpoA insert domain
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF01000 (RNA polymerase Rpb3/RpoA insert domain) in DNA-directed RNA polymerases I and III subunit RPAC1. Showing 1 copy in chain C.

PF01193
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerases I and III subunit RPAC1. Showing 1 copy in chain C.

PF04560
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04560 (RNA polymerase Rpb2, domain 7) in DNA-directed RNA polymerase I subunit RPA2. Showing 1 copy in chain B.

PF00562
Domain description: RNA polymerase Rpb2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF00562 (RNA polymerase Rpb2, domain 6) in DNA-directed RNA polymerase I subunit RPA2. Showing 1 copy in chain B.

PF06883
Domain description: RNA polymerase I, Rpa2 specific domain
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF06883 (RNA polymerase I, Rpa2 specific domain) in DNA-directed RNA polymerase I subunit RPA2. Showing 1 copy in chain B.

PF04565
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04565 (RNA polymerase Rpb2, domain 3) in DNA-directed RNA polymerase I subunit RPA2. Showing 1 copy in chain B.

PF04561
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04561 (RNA polymerase Rpb2, domain 2) in DNA-directed RNA polymerase I subunit RPA2. Showing 1 copy in chain B.

PF04563
Domain description: RNA polymerase beta subunit
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04563 (RNA polymerase beta subunit) in DNA-directed RNA polymerase I subunit RPA2. Showing 1 copy in chain B.

PF04998
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04998 (RNA polymerase Rpb1, domain 5) in DNA-directed RNA polymerase I subunit RPA1. Showing 1 copy in chain A.

PF05000
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF05000 (RNA polymerase Rpb1, domain 4) in DNA-directed RNA polymerase I subunit RPA1. Showing 1 copy in chain A.

PF04983
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04983 (RNA polymerase Rpb1, domain 3) in DNA-directed RNA polymerase I subunit RPA1. Showing 1 copy in chain A.

PF00623
Domain description: RNA polymerase Rpb1, domain 2
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF00623 (RNA polymerase Rpb1, domain 2) in DNA-directed RNA polymerase I subunit RPA1. Showing 1 copy in chain A.

PF04997
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
The deposited structure of PDB entry 8a43 contains 1 copy of Pfam domain PF04997 (RNA polymerase Rpb1, domain 1) in DNA-directed RNA polymerase I subunit RPA1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001222
Domain description: Zinc finger, TFIIS-type
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA12
IPR005570
Domain description: DNA-directed RNA polymerases I, II, and III subunit RPABC3
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
IPR036603
Domain description: RNA polymerase, RBP11-like subunit
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
  2. DNA-directed RNA polymerases I and III subunit RPAC2
IPR000268
Domain description: DNA-directed RNA polymerase subunit RPABC5/Rpb10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR014381
Domain description: DNA-directed RNA polymerase subunit Rpo5/Rpb5
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR009668
Domain description: RNA polymerase I associated factor, A49-like
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA49
IPR013240
Domain description: DNA-directed RNA polymerase I, subunit RPA34
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA34
IPR006591
Domain description: RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR012164
Domain description: DNA-directed RNA polymerase subunit/transcription factor S
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA12
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
IPR006110
Domain description: RNA polymerase, subunit omega/Rpo6/RPB6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR036161
Domain description: RPB6/omega subunit-like superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR035913
Domain description: RPB5-like RNA polymerase subunit superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR036710
Domain description: RNA polymerase Rpb5, N-terminal domain superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR036643
Domain description: DNA-directed RNA polymerase, insert domain superfamily
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
IPR011263
Domain description: DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
IPR015712
Domain description: DNA-directed RNA polymerase, subunit 2
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR029040
Domain description: RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR039747
Domain description: DNA-directed RNA polymerases I, II, and III subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR008193
Domain description: DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC2
IPR009025
Domain description: DNA-directed RNA polymerase, RBP11-like dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC2
IPR022905
Domain description: DNA-directed RNA polymerase subunit Rpo11-like
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC2
IPR033898
Domain description: DNA-directed RNA polymerases I and III subunit AC19
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC2
IPR020789
Domain description: RNA polymerases, subunit N, zinc binding site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR023580
Domain description: RNA polymerase subunit RPB10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR034004
Domain description: Pol I subunit A12, C-terminal zinc ribbon
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA12
IPR019761
Domain description: DNA-directed RNA polymerase M, 15kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA12
IPR020708
Domain description: DNA-directed RNA polymerase, 14-18kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR028363
Domain description: DNA-directed RNA polymerase, subunit RPB6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR006111
Domain description: Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR020608
Domain description: RNA polymerase, subunit H/Rpb5, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR000783
Domain description: RNA polymerase, subunit H/Rpb5 C-terminal
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR005571
Domain description: RNA polymerase, Rpb5, N-terminal
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR011262
Domain description: DNA-directed RNA polymerase, insert domain
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
IPR001514
Domain description: DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
IPR022842
Domain description: DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
IPR033901
Domain description: DNA-directed RNA polymerases I and III subunit AC40
Occurring in:
  1. DNA-directed RNA polymerases I and III subunit RPAC1
IPR007641
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR007121
Domain description: RNA polymerase, beta subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR014724
Domain description: RNA polymerase Rpb2, OB-fold
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR037033
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR007120
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR009674
Domain description: DNA-directed RNA polymerase I subunit RPA2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR007645
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR037034
Domain description: RNA polymerase Rpb2, domain 2 superfamily
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR007642
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR007644
Domain description: RNA polymerase, beta subunit, protrusion
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA2
IPR047107
Domain description: DNA-directed RNA pol I, largest subunit, C-terminal domain
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR007081
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR007083
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR038120
Domain description: RNA polymerase Rpb1, funnel domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR042102
Domain description: RNA polymerase Rpb1, domain 3 superfamily
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR007066
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR000722
Domain description: RNA polymerase, alpha subunit
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR006592
Domain description: RNA polymerase, N-terminal
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR045867
Domain description: DNA-directed RNA polymerase, subunit beta-prime
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR015699
Domain description: DNA-directed RNA pol I, largest subunit, N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR007080
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1
IPR044893
Domain description: RNA polymerase Rpb1, clamp domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase I subunit RPA1

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