› 8a7l

X-ray diffraction
1.85Å resolution

PcIDS1 in complex with Mg2+, GPP, and ZOL

Released:
DOI: 10.2210/pdb8a7l/pdb
PDB entry 8a7l coloured by chain, front view.
PDB entry 8a7l coloured by chain, side view.
PDB entry 8a7l coloured by chain, top view.
Source organism: Phaedon cochleariae
Primary publication:
Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors.
Ecker F, Vattekkatte A, Boland W, Groll M
Nat Chem (2023)
PMID: 37308711

Function and Biology Details

Reaction catalysed: 
Prenyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216648 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 39.98 KDa
Source organism: Phaedon cochleariae
Expression system: Escherichia coli
UniProt:
  • Canonical: M1JS91 (Residues: 86-429; Coverage: 80%)
Sequence domains: Polyprenyl synthetase

Ligands and Environments

4 bound ligands:
Ligand MG 3 x MG
Ligand GOL 1 x GOL
Ligand ZOL 1 x ZOL
Ligand GPP 1 x GPP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 86.17Å b: 86.17Å c: 119.61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.149 0.147 0.182
Expression system: Escherichia coli

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