› 8ade

Electron Microscopy
2.78Å resolution

Wild type ATTR amyloid fibril from senile systemic amyloidosis

Released:
DOI: 10.2210/pdb8ade/pdb
PDB entry 8ade coloured by chain, front view.
PDB entry 8ade coloured by chain, side view.
PDB entry 8ade coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis.
Steinebrei M, Gottwald J, Baur J, Röcken C, Hegenbart U, Schönland S, Schmidt M
Nat Commun 13 6398 (2022)
PMID: 36302762
Related structures: EMD-15361

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.78Å
Relevant EMDB volumes: EMD-15361

Quick links

Citations

2 review citations

Thiophene-Based Ligands: Design, Synthesis and Their Utilization for Optical Assignment of Polymorphic-Disease-Associated Protein Aggregates.
Björk et al. (2023)
1 more

1 mention without citation

Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis.
Steinebrei et al. (2023)