› 8adw

Electron Microscopy
2.95Å resolution

Lipidic alpha-synuclein fibril - polymorph L1C

Released:
DOI: 10.2210/pdb8adw/pdb
PDB entry 8adw coloured by chain, front view.
PDB entry 8adw coloured by chain, side view.
PDB entry 8adw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 3D structure of lipidic fibrils of α-synuclein.
Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, de Groot BL, Andreas LB, Becker S, Griesinger C, Schröder GF
OpenAccess logo Nat Commun 13 6810 (2022)
PMID: 36357403
Related structures: EMD-15372

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-543898 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.95Å
Relevant EMDB volumes: EMD-15372
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
7 more