› 8aic

X-ray diffraction
2.8Å resolution

X-ray structure of the receptor binding domain of Env glycoprotein of Simian Foamy virus

Released:
DOI: 10.2210/pdb8aic/pdb
PDB entry 8aic coloured by chain, front view.
PDB entry 8aic coloured by chain, side view.
PDB entry 8aic coloured by chain, top view.
Source organism: Simian foamy virus
Primary publication:
The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.
Fernández I, Dynesen LT, Coquin Y, Pederzoli R, Brun D, Haouz A, Gessain A, Rey FA, Buseyne F, Backovic M
OpenAccess logo Nat Commun 14 1262 (2023)
PMID: 36878926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125632 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Envelope glycoprotein gp130 Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 40.29 KDa
Source organism: Simian foamy virus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: K7YEW5 (Residues: 218-552; Coverage: 34%)
Gene name: env
Sequence domains: Foamy virus envelope protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P61
Unit cell:
a: 123.624Å b: 123.624Å c: 191.611Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.229
Expression system: Drosophila melanogaster

Quick links

Citations

1 mention without citation

Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus.
Dynesen et al. (2023)