› 8ajr

Solution NMR

The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2

Released:
DOI: 10.2210/pdb8ajr/pdb
PDB entry 8ajr coloured by chain, ensemble of 10 models, front view.
PDB entry 8ajr coloured by chain, ensemble of 10 models, side view.
PDB entry 8ajr coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Epigenetic CpG duplex marks probed by an evolved DNA reader via a well-tempered conformational plasticity.
Singh H, Das CK, Buchmuller BC, Schäfer LV, Summerer D, Linser R
OpenAccess logo Nucleic Acids Res (2023)
PMID: 36919612

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methyl-CpG-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51608 (Residues: 89-181; Coverage: 19%)
Gene name: MECP2
Sequence domains: Methyl-CpG binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 72%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Epigenetic CpG duplex marks probed by an evolved DNA reader via a well-tempered conformational plasticity.
Singh et al. (2023)