› 8amo

X-ray diffraction
1.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161992 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 143 Chain: A
Molecule details ›
Chain: A
Length: 399 amino acids
Theoretical weight: 44.42 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPL3 (Residues: 2-393; Coverage: 100%)
Gene names: MTV049.07c, Rv1785c, cyp143
Sequence domains: Cytochrome P450

Ligands and Environments

3 bound ligands:
Ligand HEM 1 x HEM
Ligand CL 1 x CL
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P1
Unit cell:
a: 42.21Å b: 48.53Å c: 54.15Å
α: 111.652° β: 99.502° γ: 109.34°
R-values:
R R work R free
0.171 0.17 0.2
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes.
Yang et al. (2023)

1 mention without citation

Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450.
Gilep et al. (2022)