› 8ani

X-ray diffraction
1.35Å resolution

Structure of the amyloid-forming peptide LYIQWL from Tc5b, grown from 10% ethanol

Released:
DOI: 10.2210/pdb8ani/pdb
PDB entry 8ani coloured by chain, front view.
PDB entry 8ani coloured by chain, side view.
PDB entry 8ani coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation.
Horváth D, Dürvanger Z, K Menyhárd D, Sulyok-Eiler M, Bencs F, Gyulai G, Horváth P, Taricska N, Perczel A
OpenAccess logo Nat Commun 14 4621 (2023)
PMID: 37528104

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-222395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptide LYIQWL from Tc5b Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 amino acids
Theoretical weight: 835 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand TFA 1 x TFA
Ligand EOH 2 x EOH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU PhotonJet-R
Spacegroup: P21
Unit cell:
a: 11.719Å b: 23.467Å c: 18.762Å
α: 90° β: 90.04° γ: 90°
R-values:
R R work R free
0.118 0.114 0.152
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release.
Bosch-Camós et al. (2024)

1 mention without citation

Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation.
Horváth et al. (2023)