Structure analysis

CryoEM structure of the Chikungunya virus nsP1 capping pores in complex with m7GTP and SAH ligands

Electron Microscopy
2.7Å resolution
Assembly composition:
homo dodecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dodecamer
Accessible surface area: 193569.45 Å2
Buried surface area: 104210.46 Å2
Dissociation area: 45,690.6 Å2
Dissociation energy (ΔGdiss): 484.73 kcal/mol
Dissociation entropy (TΔSdiss): 176.9 kcal/mol
Symmetry number: 12
PDBe Complex ID: PDB-CPX-185035

Macromolecules

Chains: A, C, E, G, I, K, M, O, Q, S, V, X
Length: 543 amino acids
Theoretical weight: 60.95 KDa
Source organism: Chikungunya virus strain S27-African prototype
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q8JUX6 (Residues: 1-535; Coverage: 22%)
Pfam: Viral methyltransferase
InterPro: Alphavirus-like methyltransferase domain
PDBe-KB: UniProt Coverage View: Q8JUX6  
154350100150200250300350400450500
 
200400
UniProt
Q8JUX6
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation

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