› 8aqf

X-ray diffraction
1.55Å resolution

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND LEI-515

Released:
DOI: 10.2210/pdb8aqf/pdb
PDB entry 8aqf coloured by chain, front view.
PDB entry 8aqf coloured by chain, side view.
PDB entry 8aqf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jiang M, Huizenga M, Wirt J, Paloczi J, Amedi A, van der Berg R, Benz J, Collin L, Deng H, Driever W, Florea B, Grether U, Janssen A, Heitman L, Lam TW, Mohr F, Pavlovic A, Ruf I, Rutjes H, Stevens F, van der Vliet D, van der Wel T, Wittwer M, Boeckel C, Pacher P, Hohmann A, van der Stelt M

Function and Biology Details

Reaction catalysed: 
Hydrolyzes glycerol monoesters of long-chain fatty acids
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monoglyceride lipase Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 35.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99685 (Residues: 1-303; Coverage: 100%)
Gene name: MGLL
Sequence domains: Serine aminopeptidase, S33

Ligands and Environments

1 bound ligand:
Ligand NUX 1 x NUX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 91.625Å b: 127.568Å c: 60.358Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.154 0.178
Expression system: Escherichia coli

Quick links