› 8ar1

Solution NMR

Solution structure of TLR3 transmembrane and cytoplasmic juxtamembrane regions

Released:
DOI: 10.2210/pdb8ar1/pdb
PDB entry 8ar1 coloured by chain, ensemble of 10 models, front view.
PDB entry 8ar1 coloured by chain, ensemble of 10 models, side view.
PDB entry 8ar1 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors.
Kornilov FD, Shabalkina AV, Lin C, Volynsky PE, Kot EF, Kayushin AL, Lushpa VA, Goncharuk MV, Arseniev AS, Goncharuk SA, Wang X, Mineev KS
OpenAccess logo Nat Commun 14 1503 (2023)
PMID: 36932058

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-518557 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 50 amino acids
Theoretical weight: 6.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15455 (Residues: 698-746; Coverage: 6%)
Gene name: TLR3
Sequence domains: Toll-like receptor 3 trans-membrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Recent Advances in Studying Toll-like Receptors with the Use of Computational Methods.
Bzówka et al. (2023)
1 more

1 mention without citation

The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors.
Kornilov et al. (2023)