› 8atu

Electron Microscopy
3.3Å resolution

Cryo-EM structure of human BIRC6

Released:
DOI: 10.2210/pdb8atu/pdb
PDB entry 8atu coloured by chain, front view.
PDB entry 8atu coloured by chain, side view.
PDB entry 8atu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T
Science eade8873 (2023)
PMID: 36758105
Related structures: EMD-15663

Function and Biology Details

Reaction catalysed: 
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192524 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 4867 amino acids
Theoretical weight: 532.01 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NR09 (Residues: 1-4857; Coverage: 100%)
Gene names: BIRC6, KIAA1289
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-15663
Expression system: Trichoplusia ni

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Citations

1 review citation

Characterization of host substrates of SARS-CoV-2 main protease.
Melano et al. (2023)
9 other articles