› 8au4

Solution NMR

Structural insights reveal a heterotetramer between oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator

Released:
DOI: 10.2210/pdb8au4/pdb
PDB entry 8au4 coloured by chain, ensemble of 20 models, front view.
PDB entry 8au4 coloured by chain, ensemble of 20 models, side view.
PDB entry 8au4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator.
Tariq M, Ikeya T, Togashi N, Fairall L, Kamei S, Mayooramurugan S, Abbott LR, Hasan A, Bueno-Alejo C, Sukegawa S, Romartinez-Alonso B, Muro Campillo MA, Hudson AJ, Ito Y, Schwabe JW, Dominguez C, Tanaka K
OpenAccess logo Life Sci Alliance 7 (2024)
PMID: 37833074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-518406 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ral guanine nucleotide dissociation stimulator-like 2 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15211 (Residues: 643-740; Coverage: 13%)
Gene names: RAB2L, RGL2
Sequence domains: Ras association (RalGDS/AF-6) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: energy minimization
Expression system: Escherichia coli BL21(DE3)

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