8avc

Electron Microscopy
4.6Å resolution

Mouse leptin:LEP-R complex cryoEM structure (3:3 model)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-214911 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leptin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 174 amino acids
Theoretical weight: 18.87 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41160 (Residues: 21-167; Coverage: 100%)
Gene names: Lep, Ob
Sequence domains: Leptin
Leptin receptor Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 868 amino acids
Theoretical weight: 97.48 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P48356 (Residues: 22-839; Coverage: 72%)
  • Best match: P48356-5 (Residues: 22-796)
Gene names: Db, Lepr, Obr
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-15678
Expression systems:
  • Escherichia coli BL21(DE3)
  • Homo sapiens