› 8ayf

X-ray diffraction
1.84Å resolution

Function and Biology Details

Reaction catalysed: 
Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131939 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sphingosine-1-phosphate lyase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 494 amino acids
Theoretical weight: 55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O95470 (Residues: 81-568; Coverage: 86%)
Gene names: KIAA1252, SGPL1
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand GOL 2 x GOL
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 59.16Å b: 127.41Å c: 66.95Å
α: 90° β: 104.85° γ: 90°
R-values:
R R work R free
0.192 0.191 0.214
Expression system: Escherichia coli BL21

Quick links

Citations

1 mention without citation

Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.
Cellini et al. (2023)

PDB-REDO

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