› 8az0

Electron Microscopy
3.4Å resolution

IAPP S20G growth-phase fibril polymorph 2PF-L

Released:
DOI: 10.2210/pdb8az0/pdb
PDB entry 8az0 coloured by chain, front view.
PDB entry 8az0 coloured by chain, side view.
PDB entry 8az0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evolution of fibril polymorphs during amyloid assembly.
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell 186 5798-5811.e26 (2023)
PMID: 38134875
Related structures: EMD-15728

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 38 amino acids
Theoretical weight: 3.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-15728
Expression system: Not provided

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