› 8az4

Electron Microscopy
2.2Å resolution

IAPP S20G plateau-phase fibril polymorph 2PF-L

Released:
DOI: 10.2210/pdb8az4/pdb
PDB entry 8az4 coloured by chain, front view.
PDB entry 8az4 coloured by chain, side view.
PDB entry 8az4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evolution of fibril polymorphs during amyloid assembly.
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell 186 5798-5811.e26 (2023)
PMID: 38134875
Related structures: EMD-15753

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Islet amyloid polypeptide Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 38 amino acids
Theoretical weight: 3.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10997 (Residues: 34-70; Coverage: 55%)
Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.2Å
Relevant EMDB volumes: EMD-15753
Expression system: Not provided

Quick links

Citations

3 citation in other articles

Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways.
Dewison et al. (2024)
2 more