› 8azv

X-ray diffraction
1.05Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 1-164; Coverage: 87%)
  • Best match: P01116-2 (Residues: 1-164)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family

Ligands and Environments

4 bound ligands:
Ligand GDP 1 x GDP
Ligand MG 1 x MG
Ligand EDO 2 x EDO
Ligand OFU 1 x OFU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 86.47Å b: 40.632Å c: 56.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.155 0.174
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Precision Oncology: 2023 in Review.
Murciano-Goroff et al. (2023)
9 more