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8b00 Overview
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8b00</span> coloured by chain, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_deposited_chain_front_image-800x800.png "PDB entry 8b00 coloured by chain, front view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8b00</span> coloured by chain, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_deposited_chain_side_image-800x800.png "PDB entry 8b00 coloured by chain, side view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8b00</span> coloured by chain, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_deposited_chain_top_image-800x800.png "PDB entry 8b00 coloured by chain, top view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8b00</span> coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_deposited_chemically_distinct_molecules_front_image-800x800.png "PDB entry 8b00 coloured by chemically distinct molecules, front view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8b00</span> coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_deposited_chemically_distinct_molecules_side_image-800x800.png "PDB entry 8b00 coloured by chemically distinct molecules, side view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8b00</span> coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_deposited_chemically_distinct_molecules_top_image-800x800.png "PDB entry 8b00 coloured by chemically distinct molecules, top view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>8b00</span> contains 1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>. Front view.</div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_entity_5_front_image-800x800.png "(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile in PDB entry 8b00, assembly 1, front view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>8b00</span> coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_assembly_1_chemically_distinct_molecules_front_image-800x800.png "Monomeric assembly 1 of PDB entry 8b00 coloured by chemically distinct molecules, front view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>8b00</span> coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_assembly_1_chemically_distinct_molecules_side_image-800x800.png "Monomeric assembly 1 of PDB entry 8b00 coloured by chemically distinct molecules, side view.")
![<div class='caption-body'>Monomeric assembly 1 of PDB entry <span class='highlight'>8b00</span> coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>GTPase KRas, N-terminally processed</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>GUANOSINE-5'-DIPHOSPHATE</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>MAGNESIUM ION</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>1,2-ETHANEDIOL</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>(4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>water</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8b00_assembly_1_chemically_distinct_molecules_top_image-800x800.png "Monomeric assembly 1 of PDB entry 8b00 coloured by chemically distinct molecules, top view.")