Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thrombospondin type-1 (TSP1) repeat
- Membrane attack complex component/perforin/complement C9
- Low-density lipoprotein (LDL) receptor class A repeat
- Thrombospondin type-1 (TSP1) repeat superfamily
- Sushi/SCR/CCP domain
- Membrane attack complex component/perforin (MACPF) domain
- LDL receptor-like superfamily
- Alpha-1-microglobulin
31 more domains
Structure analysis Details
Assembly composition:
hetero heptamer (preferred)
Assembly name:
C5b6 complement complex (preferred)
PDBe Complex ID:
PDB-CPX-133868 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (9 distinct):
Complement C5
Molecule details ›
Chain: A
Length: 1676 amino acids
Theoretical weight: 188.51 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 1676 amino acids
Theoretical weight: 188.51 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P01031 (Residues: 1-1676; Coverage: 100%)
Sequence domains:
- Macroglobulin domain MG1
- MG2 domain
- Macroglobulin domain MG3
- Macroglobulin domain MG4
- Alpha-2-macroglobulin bait region domain
- Anaphylotoxin-like domain
- Alpha-2-macroglobulin family
- A-macroglobulin TED domain
- Complement component 5, CUB domain
- A-macroglobulin receptor binding domain
- UNC-6/NTR/C345C module
Complement component C6
Molecule details ›
Chain: B
Length: 934 amino acids
Theoretical weight: 104.92 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 934 amino acids
Theoretical weight: 104.92 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P13671 (Residues: 1-934; Coverage: 100%)
Sequence domains:
Complement component C7
Molecule details ›
Chain: C
Length: 843 amino acids
Theoretical weight: 93.63 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 843 amino acids
Theoretical weight: 93.63 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P10643 (Residues: 1-843; Coverage: 100%)
Sequence domains:
Complement component C8 beta chain
Molecule details ›
Chain: D
Length: 591 amino acids
Theoretical weight: 67.14 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 591 amino acids
Theoretical weight: 67.14 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P07358 (Residues: 1-591; Coverage: 100%)
Sequence domains:
Complement component C8 alpha chain
Molecule details ›
Chain: E
Length: 584 amino acids
Theoretical weight: 65.24 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 584 amino acids
Theoretical weight: 65.24 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P07357 (Residues: 1-584; Coverage: 100%)
Sequence domains:
Complement component C8 gamma chain
Molecule details ›
Chain: F
Length: 202 amino acids
Theoretical weight: 22.3 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Length: 202 amino acids
Theoretical weight: 22.3 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P07360 (Residues: 1-202; Coverage: 100%)
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
CD59 glycoprotein
Molecule details ›
Chain: G
Length: 120 amino acids
Theoretical weight: 13.36 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
Sequence domains: u-PAR/Ly-6 domain
Length: 120 amino acids
Theoretical weight: 13.36 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
- Canonical: P13987 (Residues: 1-120; Coverage: 92%)
Sequence domains: u-PAR/Ly-6 domain
