8b42

Electron Microscopy
6.6Å resolution

Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel.

Released:
Source organism: Mus musculus
Primary publication:
Structure of a volume-regulated heteromeric LRRC8A/C channel.
OpenAccess logo Nat Struct Mol Biol (2022)
PMID: 36522427
Related structures: EMD-15837

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-216426 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Volume-regulated anion channel subunit LRRC8A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 817 amino acids
Theoretical weight: 95.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q80WG5 (Residues: 2-810; Coverage: 100%)
Gene names: Lrrc8, Lrrc8a
Sequence domains:
Volume-regulated anion channel subunit LRRC8C Chains: E, F
Molecule details ›
Chains: E, F
Length: 811 amino acids
Theoretical weight: 93.47 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8R502 (Residues: 2-803; Coverage: 100%)
Gene names: Ad158, Fad158, Lrrc8c
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.6Å
Relevant EMDB volumes: EMD-15837
Expression system: Homo sapiens