› 8b5x

X-ray diffraction
1.98Å resolution

Crystal structure of the SUN1-KASH6 9:6 complex

Released:
DOI: 10.2210/pdb8b5x/pdb
Model geometry
Fit model/data
PDB entry 8b5x coloured by chain, front view.
PDB entry 8b5x coloured by chain, side view.
PDB entry 8b5x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion.
Gurusaran M, Erlandsen BS, Davies OR
Commun Biol 7 138 (2024)
PMID: 38291267

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271906 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SUN domain-containing protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 203 amino acids
Theoretical weight: 22.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94901 (Residues: 589-785; Coverage: 25%)
Gene names: KIAA0810, SUN1, UNC84A
Sequence domains: Sad1 / UNC-like C-terminal
Processed inositol 1,4,5-triphosphate receptor associated 2 Chains: D, E
Molecule details ›
Chains: D, E
Length: 44 amino acids
Theoretical weight: 4.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12912 (Residues: 515-555; Coverage: 7%)
Gene names: IRAG2, JAW1, LRMP

Ligands and Environments

2 bound ligands:
Ligand K 3 x K
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P63
Unit cell:
a: 133.921Å b: 133.921Å c: 106.581Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.173 0.211
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Life outside the LINC complex - Do SUN proteins have LINC-independent functions?
Belaadi et al. (2024)

1 mention without citation

The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion.
Gurusaran et al. (2024)