› 8b7l

X-ray diffraction
1.24Å resolution

X-ray structure of Auranofin-horse spleen ferritin

Released:
DOI: 10.2210/pdb8b7l/pdb
PDB entry 8b7l coloured by chain, front view.
PDB entry 8b7l coloured by chain, side view.
PDB entry 8b7l coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Evaluation of Auranofin Loading within Ferritin Nanocages.
Lucignano R, Pratesi A, Imbimbo P, Monti DM, Picone D, Messori L, Ferraro G, Merlino A
OpenAccess logo Int J Mol Sci 23 (2022)
PMID: 36430642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-526965 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin light chain Chain: AAA
Molecule details ›
Chain: AAA
Length: 174 amino acids
Theoretical weight: 19.87 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P02791 (Residues: 2-175; Coverage: 99%)
Gene name: FTL
Sequence domains: Ferritin-like domain

Ligands and Environments

4 bound ligands:
Ligand CD 9 x CD
Ligand SO4 1 x SO4
Ligand AU 1 x AU
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: F432
Unit cell:
a: 181.99Å b: 181.99Å c: 181.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.158 0.18

Quick links

Citations

1 mention without citation

Evaluation of Auranofin Loading within Ferritin Nanocages.
Lucignano et al. (2022)