Function and Biology

Cryo-EM structure of MLE in complex with ADP:AlF4

Source organism: Drosophila melanogaster
Biochemical function: lncRNA binding
Biological process: regulation of cytoplasmic translation
Cellular component: ribonucleoprotein complex

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

Sequence families

Pfam Protein families (Pfam)
PF00035
Domain description: Double-stranded RNA binding motif
Occurring in:
  1. Dosage compensation regulator mle
The deposited structure of PDB entry 8b9j contains 2 copies of Pfam domain PF00035 (Double-stranded RNA binding motif) in Dosage compensation regulator mle. Showing 2 copies in chain A (this domain is out of the observed residue ranges!).

PF07717
Domain description: Oligonucleotide/oligosaccharide-binding (OB)-fold
Occurring in:
  1. Dosage compensation regulator mle
The deposited structure of PDB entry 8b9j contains 1 copy of Pfam domain PF07717 (Oligonucleotide/oligosaccharide-binding (OB)-fold) in Dosage compensation regulator mle. Showing 1 copy in chain A.

PF21010
Domain description: Helicase associated domain (HA2), ratchet-like
Occurring in:
  1. Dosage compensation regulator mle
The deposited structure of PDB entry 8b9j contains 1 copy of Pfam domain PF21010 (Helicase associated domain (HA2), ratchet-like) in Dosage compensation regulator mle. Showing 1 copy in chain A.

PF04408
Domain description: Helicase associated domain (HA2), winged-helix
Occurring in:
  1. Dosage compensation regulator mle
The deposited structure of PDB entry 8b9j contains 1 copy of Pfam domain PF04408 (Helicase associated domain (HA2), winged-helix) in Dosage compensation regulator mle. Showing 1 copy in chain A.

PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. Dosage compensation regulator mle
The deposited structure of PDB entry 8b9j contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Dosage compensation regulator mle. Showing 1 copy in chain A.

PF00270
Domain description: DEAD/DEAH box helicase
Occurring in:
  1. Dosage compensation regulator mle
The deposited structure of PDB entry 8b9j contains 1 copy of Pfam domain PF00270 (DEAD/DEAH box helicase) in Dosage compensation regulator mle. Showing 1 copy in chain A.