PDB 8b9z structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)

Biochemical function:

NADH dehydrogenase (ubiquinone) activity

Biological process:

mitochondrial electron transport, NADH to ubiquinone

Cellular component:

respiratory chain complex I

Sequence domains:

78 more domains

Structure analysis Details

Assembly composition:

hetero 43-mer (preferred)

PDBe Complex ID:

PDB-CPX-222813 (preferred)

Entry contents:

42 distinct polypeptide molecules

Macromolecules (42 distinct):

NADH-ubiquinone oxidoreductase chain 3 Chain: A

Molecule details ›

Chain: A
Length: 117 amino acids
Theoretical weight: 13.57 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18930 (Residues: 1-117; Coverage: 100%)

Gene names: ND3, mt:ND3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein Chain: B

Molecule details ›

Chain: B
Length: 182 amino acids
Theoretical weight: 20.49 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VXK7 (Residues: 40-221; Coverage: 82%)

Gene names: 20 kDa, CG9172, Dmel\CG9172, Dmel_CG9172, ND-20, NUKM, PSST, dNDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chain: C

Molecule details ›

Chain: C
Length: 209 amino acids
Theoretical weight: 24.44 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VZU4 (Residues: 45-253; Coverage: 79%)

Gene names: CG12079, ND-30, NDUFS3
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit

Complex I-49kD Chain: D

Molecule details ›

Chain: D
Length: 430 amino acids
Theoretical weight: 48.88 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9V4E0 (Residues: 39-468; Coverage: 92%)

Gene names: CG 1970, CG1970, CG1970-RA, Dmel\CG1970, Dmel_CG1970, ND-49, NUCM, Ndufs2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit

NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform B Chain: E

Molecule details ›

Chain: E
Length: 214 amino acids
Theoretical weight: 23.98 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VX36 (Residues: 29-242; Coverage: 88%)

Gene names: BEST:LP01573, CG 5703, CG5703, Dmel\CG5703, Dmel_CG5703, ND-24, NUHM, Ndufv2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: F

Molecule details ›

Chain: F
Length: 441 amino acids
Theoretical weight: 48.26 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VMI3 (Residues: 34-474; Coverage: 93%)

Gene names: CG9140, Dmel\CG9140, Dmel_CG9140, ND-51, ND51, NDUFV1, NUBM, dNDUFV1, dNDUFV1A
Sequence domains:

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chain: G

Molecule details ›

Chain: G
Length: 731 amino acids
Theoretical weight: 78.72 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q94511 (Residues: 1-731; Coverage: 100%)

Gene names: CG2286, ND-75, ND75
Sequence domains:

NADH-ubiquinone oxidoreductase chain 1 Chain: H

Molecule details ›

Chain: H
Length: 315 amino acids
Theoretical weight: 36.38 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18929 (Residues: 1-312; Coverage: 100%)

Gene names: ND1, mt:ND1
Sequence domains: NADH dehydrogenase

NADH dehydrogenase (ubiquinone) 23 kDa subunit Chain: I

Molecule details ›

Chain: I
Length: 186 amino acids
Theoretical weight: 21.2 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VF27 (Residues: 32-217; Coverage: 86%)

Gene names: CG3944, ND-23, NUIM, dNDUFS8
Sequence domains: 4Fe-4S dicluster domain

NADH-ubiquinone oxidoreductase chain 6 Chain: J

Molecule details ›

Chain: J
Length: 173 amino acids
Theoretical weight: 20 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18933 (Residues: 1-173; Coverage: 99%)

Gene names: ND6, mt:ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6

NADH-ubiquinone oxidoreductase chain 4L Chain: K

Molecule details ›

Chain: K
Length: 96 amino acids
Theoretical weight: 11.36 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18934 (Residues: 1-96; Coverage: 100%)

Gene names: ND4L, mt:ND4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

NADH-ubiquinone oxidoreductase chain 5 Chain: L

Molecule details ›

Chain: L
Length: 577 amino acids
Theoretical weight: 65.78 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18932 (Residues: 1-572; Coverage: 100%)

Gene names: NADH5, ND5, mt:ND5
Sequence domains:

NADH-ubiquinone oxidoreductase chain 4 Chain: M

Molecule details ›

Chain: M
Length: 446 amino acids
Theoretical weight: 51.47 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18931 (Residues: 1-446; Coverage: 100%)

Gene names: CG34085, ND4, mt:ND4
Sequence domains:

NADH-ubiquinone oxidoreductase chain 2 Chain: N

Molecule details ›

Chain: N
Length: 341 amino acids
Theoretical weight: 39.84 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P03896 (Residues: 1-341; Coverage: 100%)

Gene names: NADH2, ND2, mt:ND2
Sequence domains:

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chain: O

Molecule details ›

Chain: O
Length: 368 amino acids
Theoretical weight: 42.72 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P91929 (Residues: 40-407; Coverage: 90%)

Gene names: CG6343, ND-42, NdufA10
Sequence domains: Deoxynucleoside kinase

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chain: P

Molecule details ›

Chain: P
Length: 377 amino acids
Theoretical weight: 42.99 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VPE2 (Residues: 40-416; Coverage: 91%)

Gene names: CG6020, CG6020-RA, Dmel\CG6020, Dmel_CG6020, GM13757p, ND-39, NDUFA9, NUEM, Ndufa9, dNDUFA9
Sequence domains: NAD dependent epimerase/dehydratase family

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: Q

Molecule details ›

Chain: Q
Length: 151 amino acids
Theoretical weight: 17.24 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VWI0 (Residues: 33-183; Coverage: 83%)

Gene names: CG12203, ND-18, NUYM, dNDUFS4
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chain: R

Molecule details ›

Chain: R
Length: 89 amino acids
Theoretical weight: 10.2 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VMU0 (Residues: 33-121; Coverage: 71%)

Gene names: CG8680, Dmel\CG8680, Dmel_CG8680, ND-13A, NUMM, dNDUFS6
Sequence domains: Zinc-finger domain

Acyl carrier protein, mitochondrial Chains: T, U

Molecule details ›

Chains: T, U
Length: 85 amino acids
Theoretical weight: 9.73 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q94519 (Residues: 68-152; Coverage: 56%)

Gene names: CG9160, ND-ACP, ND-AcC, mtACP, mtacp1
Sequence domains: Phosphopantetheine attachment site

RH11203p Chain: V

Molecule details ›

Chain: V
Length: 118 amino acids
Theoretical weight: 13.14 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VTB4 (Residues: 5-122; Coverage: 95%)

Gene names: BcDNA:RH11203, CG6463, Dmel\CG6463, Dmel_CG6463, ND-13B, NUFM, Q9VTB4, dNDUFA5
Sequence domains: ETC complex I subunit conserved region

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chain: W

Molecule details ›

Chain: W
Length: 114 amino acids
Theoretical weight: 13.81 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7JZK1 (Residues: 10-123; Coverage: 92%)

Gene names: BcDNA:RE25411, CG7712, Dmel\CG7712, Dmel_CG7712, NB4M, ND-B14
Sequence domains: Complex 1 protein (LYR family)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chain: X

Molecule details ›

Chain: X
Length: 174 amino acids
Theoretical weight: 19.74 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W125 (Residues: 2-175; Coverage: 99%)

Gene names: CG3683, Dmel\CG3683, Dmel_CG3683, ND-19, NDUFA8, NUPM, Ndufa8, RH23043p
Sequence domains: CHCH domain

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chain: Y

Molecule details ›

Chain: Y
Length: 167 amino acids
Theoretical weight: 18.1 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7JYH3 (Residues: 4-170; Coverage: 98%)

Gene names: BcDNA:RH51452, CG9350, Dmel\CG9350, Dmel_CG9350, ND-B14.7

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: Z

Molecule details ›

Chain: Z
Length: 146 amino acids
Theoretical weight: 16.96 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W402 (Residues: 9-154; Coverage: 95%)

Gene names: CG3446, Dmel\CG3446, Dmel_CG3446, NB6M, ND-B16.6
Sequence domains: GRIM-19 protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: a

Molecule details ›

Chain: a
Length: 73 amino acids
Theoretical weight: 8.59 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: A8DYC5 (Residues: 1-73; Coverage: 100%)

Gene names: BcDNA:RH49308, CG13328, CG17054, CG30057, CG34439, CG34439-RA, Dmel\CG34439, Dmel_CG34439, ND-MWFE, l(2)c00093
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chain: b

Molecule details ›

Chain: b
Length: 66 amino acids
Theoretical weight: 7.38 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W380 (Residues: 11-76; Coverage: 86%)

Gene names: CG9034, NdufA3, Prto

NADH dehydrogenase [ubiquinone] 1 subunit C2 Chain: d

Molecule details ›

Chain: d
Length: 115 amino acids
Theoretical weight: 12.79 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VQM2 (Residues: 2-116; Coverage: 99%)

Gene names: BcDNA:RE29623, CG12400, Dmel\CG12400, Dmel_CG12400, N4BM, ND-B14.5B, Q9VQM2, dNDUFC2
Sequence domains: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)

NADH dehydrogenase (Ubiquinone) 15 kDa subunit, isoform G Chain: e

Molecule details ›

Chain: e
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7K1C0 (Residues: 2-101; Coverage: 99%)

Gene names: CG11455, CG11455-RB, CG3436, Dmel\CG11455, Dmel_CG11455, ND-15, NIPM, dNDUFS5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chain: f

Molecule details ›

Chain: f
Length: 55 amino acids
Theoretical weight: 6.1 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W3N7 (Residues: 2-56; Coverage: 98%)

Gene names: CG15328, CG18624, CG18624-RA, CG18624-RB, Dmel\CG18624, Dmel_CG18624, ND-MNLL, NINM
Sequence domains: MNLL subunit

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chain: g

Molecule details ›

Chain: g
Length: 108 amino acids
Theoretical weight: 12.48 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9V3L7 (Residues: 43-150; Coverage: 72%)

Gene names: CG6008, Dmel\CG6008, Dmel_CG6008, NP15.6, anon-WO0118547.281
Sequence domains: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chain: h

Molecule details ›

Chain: h
Length: 145 amino acids
Theoretical weight: 17.45 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VTU2 (Residues: 42-186; Coverage: 78%)

Gene names: CG9762, Dmel\CG9762, Dmel_CG9762, ND-SGDH, NISM, Q9VTU2, dND-SGDH, dNDUFB5, l(3)neo18
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

NADH dehydrogenase (Ubiquinone) B17 subunit, isoform A Chain: i

Molecule details ›

Chain: i
Length: 161 amino acids
Theoretical weight: 18.47 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9V3W2 (Residues: 5-165; Coverage: 96%)

Gene names: BG:DS09217.1, BcDNA:GM23292, CG13240, Dmel\CG13240, Dmel_CG13240, NB7M, ND-B17, dNDUFB6, l(2)35Di
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit

GEO11417p1 Chain: j

Molecule details ›

Chain: j
Length: 66 amino acids
Theoretical weight: 7.62 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7PL91 (Residues: 27-92; Coverage: 70%)

Gene names: CG40002, CG40472, CR40472, Dmel\CG40002, Dmel\CG40472, Dmel_CG40002, Dmel_CG40472, ND-AGGG, ND-AGGGL, dNDUFB2A, dNDUFB2B, l7A
Sequence domains: NADH dehydrogenase 1 beta subcomplex subunit 2

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chain: k

Molecule details ›

Chain: k
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W2E8 (Residues: 7-90; Coverage: 76%)

Gene names: 10320, CG10320, Dmel\CG10320, Dmel_CG10320, NB2M, ND-B12, anon-EST:Posey47, anon-EST:Posey84
Sequence domains: NADH-ubiquinone oxidoreductase B12 subunit family

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chain: l

Molecule details ›

Chain: l
Length: 146 amino acids
Theoretical weight: 17.14 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W3X7 (Residues: 30-175; Coverage: 83%)

Gene names: CG3192, CG3192-RA, Dmel\CG3192, Dmel_CG3192, ND-ASHI, NIAM
Sequence domains: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chain: m

Molecule details ›

Chain: m
Length: 108 amino acids
Theoretical weight: 12.61 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q6IDF5 (Residues: 6-113; Coverage: 96%)

Gene names: CG 12859, CG12859, Dmel\CG12859, Dmel_CG12859, NB5M, ND-B15, anon-EST:fe3B12
Sequence domains: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: n

Molecule details ›

Chain: n
Length: 134 amino acids
Theoretical weight: 16.29 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VJZ4 (Residues: 2-135; Coverage: 93%)

Gene names: CG9306, Dmel\CG9306, Dmel_CG9306, ND-B22, NI2M, Ndufb9, Q9VJZ4, dNDUFB9
Sequence domains: Complex 1 protein (LYR family)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chain: o

Molecule details ›

Chain: o
Length: 112 amino acids
Theoretical weight: 13.39 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VXZ0 (Residues: 2-113; Coverage: 96%)

Gene names: CG5548, Dmel\CG5548, Dmel_CG5548, NB8M, ND-B18
Sequence domains: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chain: p

Molecule details ›

Chain: p
Length: 151 amino acids
Theoretical weight: 18.05 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VQR2 (Residues: 4-154; Coverage: 95%)

Gene names: BcDNA:RE65754, CG8844, Dmel\CG8844, Dmel_CG8844, ND-PDSW, NIDM, PDSW, Pdsw, Q9VQR2, anon-EST:Posey91, dNDUFB10, l(2)k10101, pdsw
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chain: q

Molecule details ›

Chain: q
Length: 133 amino acids
Theoretical weight: 15.81 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VQD7 (Residues: 7-139; Coverage: 94%)

Gene names: B17.2, BcDNA:GH12382, CG3214, Dmel\CG3214, Dmel_CG3214, N7BM, ND-B17.2, Q9VQD7, anon-EST:Posey62, dNDUFA12
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chain: r

Molecule details ›

Chain: r
Length: 103 amino acids
Theoretical weight: 11.56 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: O97418 (Residues: 1-103; Coverage: 100%)

Gene names: 152A3.7, BcDNA:RE75088, CG3621, CG3621-RA, Dmel\CG3621, Dmel_CG3621, EG:152A3.7, N4AM, ND-B14.5A, RNAA, anon-2D, anon-2Db
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

RH44935p Chain: s

Molecule details ›

Chain: s
Length: 62 amino acids
Theoretical weight: 6.51 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VZ01 (Residues: 48-109; Coverage: 57%)

Gene names: BcDNA:RH44935, CG11752, Dmel\CG11752, Dmel_CG11752, NdufV3, anon-EST:Posey214
Sequence domains: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial