› 8bcy

X-ray diffraction
2.43Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126246 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A
Molecule details ›
Chain: A
Length: 1018 amino acids
Theoretical weight: 116.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00329 (Residues: 17-1034; Coverage: 98%)
Gene name: PIK3CD
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 169 amino acids
Theoretical weight: 20.88 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23727 (Residues: 431-599; Coverage: 23%)
Gene name: PIK3R1
Sequence domains: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

Ligands and Environments

1 bound ligand:
Ligand I3H 1 x I3H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 90.603Å b: 108.809Å c: 142.623Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.263
Expression system: Spodoptera frugiperda

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