› 8bdc

Electron Microscopy
2.65Å resolution

Human apo TRPM8 in a closed state (composite map)

Released:
DOI: 10.2210/pdb8bdc/pdb
PDB entry 8bdc coloured by chain, front view.
PDB entry 8bdc coloured by chain, side view.
PDB entry 8bdc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human TRPM8 channel.
Palchevskyi S, Czarnocki-Cieciura M, Vistoli G, Gervasoni S, Nowak E, Beccari AR, Nowotny M, Talarico C
OpenAccess logo Commun Biol 6 1065 (2023)
PMID: 37857704
Related structures: EMD-15981

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1105 amino acids
Theoretical weight: 127.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7Z2W7 (Residues: 2-1104; Coverage: 100%)
Gene names: LTRPC6, TRPM8, TRPP8
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand Y01 8 x Y01
Ligand POV 4 x POV
Ligand UND 4 x UND
Ligand NA 8 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.65Å
Relevant EMDB volumes: EMD-15981
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Ion channels of cold transduction and transmission.
Lewis et al. (2024)
1 more

1 mention without citation

Structure of human TRPM8 channel.
Palchevskyi et al. (2023)