Function and Biology Details
Biochemical function:
- not assigned
Biological process:
Cellular component:
Sequence domains:
- Ubiquitin-like domain
- SKP1/BTB/POZ domain superfamily
- von Hippel-Lindau disease tumour suppressor, alpha domain
- von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
- von Hippel-Lindau disease tumour suppressor, beta/alpha domain
- von Hippel-Lindau disease tumour suppressor, beta domain superfamily
- von Hippel-Lindau disease tumour suppressor, beta domain
- VHL superfamily
5 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-154086 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Elongin-B
Molecule details ›
Chains: A, D, G
Length: 104 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 104 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q15370 (Residues: 1-104; Coverage: 88%)
Sequence domains: Ubiquitin family
Elongin-C
Molecule details ›
Chains: B, E, H, K
Length: 97 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Skp1 family, tetramerisation domain
Length: 97 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Sequence domains: Skp1 family, tetramerisation domain
von Hippel-Lindau disease tumor suppressor
Molecule details ›
Chains: C, F, I, L
Length: 162 amino acids
Theoretical weight: 18.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 162 amino acids
Theoretical weight: 18.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P40337 (Residues: 54-213; Coverage: 75%)
Sequence domains:
Elongin-B
Molecule details ›
Chain: J
Length: 104 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 104 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q15370 (Residues: 1-104; Coverage: 88%)
Sequence domains: Ubiquitin family
