› 8bej

Electron Microscopy
3.24Å resolution

GABA-A receptor a5 homomer - a5V3 - APO

Released:
DOI: 10.2210/pdb8bej/pdb
PDB entry 8bej coloured by chain, front view.
PDB entry 8bej coloured by chain, side view.
PDB entry 8bej coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 37903907
Related structures: EMD-16005

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-aminobutyric acid receptor subunit alpha-5 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 360 amino acids
Theoretical weight: 41.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31644 (Residues: 32-345, 424-450; Coverage: 79%)
Gene name: GABRA5
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.24Å
Relevant EMDB volumes: EMD-16005
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

A brain-to-gut signal controls intestinal fat absorption.
Lyu et al. (2024)
1 more

1 mention without citation

The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod et al. (2023)