› 8bfb

Electron Microscopy
3.2Å resolution

Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)

Released:
DOI: 10.2210/pdb8bfb/pdb
PDB entry 8bfb coloured by chain, front view.
PDB entry 8bfb coloured by chain, side view.
PDB entry 8bfb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain.
Leistner C, Wilkinson M, Burgess A, Lovatt M, Goodbody S, Xu Y, Deuchars S, Radford SE, Ranson NA, Frank RAW
OpenAccess logo Nat Commun 14 2833 (2023)
PMID: 37198197
Related structures: EMD-16019

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 42 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 42 amino acids
Theoretical weight: 4.45 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-16019

Quick links

Citations

1 review citation

The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography.
Galaz-Montoya JG. (2024)
6 other articles