› 8bg0

Electron Microscopy
1.99Å resolution

Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40

Released:
DOI: 10.2210/pdb8bg0/pdb
PDB entry 8bg0 coloured by chain, front view.
PDB entry 8bg0 coloured by chain, side view.
PDB entry 8bg0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lövestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
OpenAccess logo Acta Neuropathol (2023)
PMID: 36611124
Related structures: EMD-16023

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-529005 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.99Å
Relevant EMDB volumes: EMD-16023

Quick links

Citations

5 review citations

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
4 more

1 mention without citation

Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Zielinski et al. (2023)