› 8bhf

Electron Microscopy
3.1Å resolution

Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4

Released:
DOI: 10.2210/pdb8bhf/pdb
PDB entry 8bhf coloured by chain, front view.
PDB entry 8bhf coloured by chain, side view.
PDB entry 8bhf coloured by chain, top view.
Source organisms:
Primary publication:
Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 37653241
Related structures: EMD-16052

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 86-mer (preferred)
PDBe Complex ID:
PDB-CPX-268549 (preferred)
Entry contents:
80 distinct polypeptide molecules
6 distinct RNA molecules
Macromolecules (86 distinct):
Large ribosomal subunit protein eL15 Chain: A1
Molecule details ›
Chain: A1
Length: 203 amino acids
Theoretical weight: 24.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T0C1 (Residues: 2-204; Coverage: 100%)
Gene name: RPL15
Sequence domains: Ribosomal L15
60S ribosomal protein L13a Chain: B1
Molecule details ›
Chain: B1
Length: 199 amino acids
Theoretical weight: 23.14 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL22 Chain: C1
Molecule details ›
Chain: C1
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SCJ6 (Residues: 2-154; Coverage: 83%)
Gene name: RPL17
Sequence domains: Ribosomal protein L22p/L17e
Ribosomal protein L18 Chain: D1
Molecule details ›
Chain: D1
Length: 187 amino acids
Theoretical weight: 21.57 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL19 Chain: E1
Molecule details ›
Chain: E1
Length: 180 amino acids
Theoretical weight: 21.61 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TYL6 (Residues: 2-181; Coverage: 92%)
Gene name: RPL19
Sequence domains: Ribosomal protein L19e
60S ribosomal protein L18a Chain: F1
Molecule details ›
Chain: F1
Length: 176 amino acids
Theoretical weight: 20.83 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein eL21 Chain: G1
Molecule details ›
Chain: G1
Length: 159 amino acids
Theoretical weight: 18.48 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHQ2 (Residues: 2-160; Coverage: 99%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
60S ribosomal protein L22 Chain: H1
Molecule details ›
Chain: H1
Length: 99 amino acids
Theoretical weight: 11.5 KDa
Source organism: Oryctolagus cuniculus
60S ribosomal protein L23 Chain: I1
Molecule details ›
Chain: I1
Length: 139 amino acids
Theoretical weight: 14.76 KDa
Source organism: Oryctolagus cuniculus
TRASH domain-containing protein Chain: J1
Molecule details ›
Chain: J1
Length: 106 amino acids
Theoretical weight: 12.27 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL23 Chain: K1
Molecule details ›
Chain: K1
Length: 118 amino acids
Theoretical weight: 13.73 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SE76 (Residues: 39-156; Coverage: 76%)
Gene name: RPL23A
Sequence domains:
Large ribosomal subunit protein uL24 Chain: L1
Molecule details ›
Chain: L1
Length: 134 amino acids
Theoretical weight: 15.89 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SQH0 (Residues: 1-134; Coverage: 92%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: M1
Molecule details ›
Chain: M1
Length: 135 amino acids
Theoretical weight: 15.7 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXF6 (Residues: 2-136; Coverage: 99%)
Gene name: RPL27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: N1
Molecule details ›
Chain: N1
Length: 147 amino acids
Theoretical weight: 16.49 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SNY0 (Residues: 2-148; Coverage: 99%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: O1
Molecule details ›
Chain: O1
Length: 116 amino acids
Theoretical weight: 13.4 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGR6 (Residues: 2-117; Coverage: 47%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: P1
Molecule details ›
Chain: P1
Length: 98 amino acids
Theoretical weight: 10.91 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDL2 (Residues: 10-107; Coverage: 85%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: Q1
Molecule details ›
Chain: Q1
Length: 107 amino acids
Theoretical weight: 12.64 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SHG0 (Residues: 18-124; Coverage: 86%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: R1
Molecule details ›
Chain: R1
Length: 128 amino acids
Theoretical weight: 15.02 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUN8 (Residues: 2-129; Coverage: 95%)
Gene name: RPL32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: S1
Molecule details ›
Chain: S1
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SF08 (Residues: 2-110; Coverage: 99%)
Gene name: RPL35A
Sequence domains: Ribosomal protein L35Ae
Large ribosomal subunit protein eL34 Chain: T1
Molecule details ›
Chain: T1
Length: 114 amino acids
Theoretical weight: 12.99 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TXG5 (Residues: 2-115; Coverage: 97%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: U1
Molecule details ›
Chain: U1
Length: 122 amino acids
Theoretical weight: 14.44 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SIT5 (Residues: 2-123; Coverage: 99%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
60S ribosomal protein L36 Chain: V1
Molecule details ›
Chain: V1
Length: 102 amino acids
Theoretical weight: 11.89 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TBH2 (Residues: 2-103; Coverage: 97%)
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: W1
Molecule details ›
Chain: W1
Length: 86 amino acids
Theoretical weight: 10.09 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: U3KPD5 (Residues: 2-87; Coverage: 89%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
Large ribosomal subunit protein eL38 Chain: X1
Molecule details ›
Chain: X1
Length: 69 amino acids
Theoretical weight: 8.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U001 (Residues: 2-70; Coverage: 99%)
Gene name: RPL38
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: Y1
Molecule details ›
Chain: Y1
Length: 50 amino acids
Theoretical weight: 6.32 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TTN1 (Residues: 2-51; Coverage: 98%)
Sequence domains: Ribosomal L39 protein
Ubiquitin-60S ribosomal protein L40 Chain: Z1
Molecule details ›
Chain: Z1
Length: 52 amino acids
Theoretical weight: 6.2 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS32 Chain: a1
Molecule details ›
Chain: a1
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A087WNH4 (Residues: 1-25; Coverage: 100%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
Large ribosomal subunit protein eL42 Chain: b1
Molecule details ›
Chain: b1
Length: 104 amino acids
Theoretical weight: 12.2 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T040 (Residues: 2-100; Coverage: 89%)
Gene name: RPL36A
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein eL43 Chain: c1
Molecule details ›
Chain: c1
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SY53 (Residues: 2-92; Coverage: 99%)
Gene name: RPL37A
Sequence domains: Ribosomal L37ae protein family
Large ribosomal subunit protein eL28 Chain: d1
Molecule details ›
Chain: d1
Length: 124 amino acids
Theoretical weight: 14.22 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U7L1 (Residues: 2-125; Coverage: 91%)
Gene name: RPL28
Sequence domains: Ribosomal L28e protein family
Large ribosomal subunit protein uL10 Chain: e1
Molecule details ›
Chain: e1
Length: 196 amino acids
Theoretical weight: 21.52 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SPK4 (Residues: 5-200; Coverage: 62%)
Gene name: RPLP0
Sequence domains:
Large ribosomal subunit protein uL11 Chain: f1
Molecule details ›
Chain: f1
Length: 153 amino acids
Theoretical weight: 16.56 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SMR7 (Residues: 9-161; Coverage: 93%)
Gene name: RPL12
Sequence domains:
60S ribosomal protein L10a Chain: l1
Molecule details ›
Chain: l1
Length: 206 amino acids
Theoretical weight: 23.6 KDa
Source organism: Oryctolagus cuniculus
CCR4-Not complex component Not N-terminal domain-containing protein Chain: n1
Molecule details ›
Chain: n1
Length: 236 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: B7Z6J7 (Residues: 1-236; Coverage: 33%)
Gene name: CNOT3
Sequence domains: Not1 N-terminal domain, CCR4-Not complex component
nascent chain Chain: 11
Molecule details ›
Chain: 11
Length: 5 amino acids
Theoretical weight: 502 Da
Source organism: Oryctolagus cuniculus
40S ribosomal protein SA Chain: B3
Molecule details ›
Chain: B3
Length: 217 amino acids
Theoretical weight: 24.36 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TJH8 (Residues: 2-218; Coverage: 77%)
Sequence domains: Ribosomal protein S2
Small ribosomal subunit protein eS1 Chain: C3
Molecule details ›
Chain: C3
Length: 213 amino acids
Theoretical weight: 24.76 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SS70 (Residues: 21-233; Coverage: 81%)
Gene name: RPS3A
Sequence domains: Ribosomal S3Ae family
40S ribosomal protein S2 Chain: D3
Molecule details ›
Chain: D3
Length: 221 amino acids
Theoretical weight: 24.44 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS3 Chain: E3
Molecule details ›
Chain: E3
Length: 228 amino acids
Theoretical weight: 25.22 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TNM3 (Residues: 1-228; Coverage: 94%)
Gene name: RPS3
Sequence domains:
Small ribosomal subunit protein eS4 Chain: F3
Molecule details ›
Chain: F3
Length: 262 amino acids
Theoretical weight: 29.52 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TK17 (Residues: 2-263; Coverage: 100%)
Gene name: RPS4X
Sequence domains:
Small ribosomal subunit protein uS7 Chain: G3
Molecule details ›
Chain: G3
Length: 191 amino acids
Theoretical weight: 21.53 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TFM5 (Residues: 14-204; Coverage: 94%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS6 Chain: H3
Molecule details ›
Chain: H3
Length: 237 amino acids
Theoretical weight: 27.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TM55 (Residues: 1-237; Coverage: 95%)
Gene name: RPS6
Sequence domains: Ribosomal protein S6e
40S ribosomal protein S7 Chain: I3
Molecule details ›
Chain: I3
Length: 189 amino acids
Theoretical weight: 21.63 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS8 Chain: J3
Molecule details ›
Chain: J3
Length: 206 amino acids
Theoretical weight: 24 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TJW1 (Residues: 2-207; Coverage: 99%)
Gene name: RPS8
Sequence domains: Ribosomal protein S8e
Small ribosomal subunit protein uS4 Chain: K3
Molecule details ›
Chain: K3
Length: 185 amino acids
Theoretical weight: 21.65 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZS8 (Residues: 2-186; Coverage: 95%)
Gene name: RPS9
Sequence domains:
Small ribosomal subunit protein eS10 Chain: L3
Molecule details ›
Chain: L3
Length: 96 amino acids
Theoretical weight: 11.53 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPV3 (Residues: 1-96; Coverage: 58%)
Sequence domains: Plectin/S10 domain
Small ribosomal subunit protein uS17 Chain: M3
Molecule details ›
Chain: M3
Length: 151 amino acids
Theoretical weight: 17.59 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TRM4 (Residues: 3-153; Coverage: 96%)
Gene name: RPS11
Sequence domains:
Small ribosomal subunit protein eS12 Chain: N3
Molecule details ›
Chain: N3
Length: 117 amino acids
Theoretical weight: 13.05 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SFR8 (Residues: 14-130; Coverage: 89%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 Chain: O3
Molecule details ›
Chain: O3
Length: 149 amino acids
Theoretical weight: 17.06 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SP51 (Residues: 2-150; Coverage: 99%)
Gene name: RPS13
Sequence domains:
Small ribosomal subunit protein uS11 Chain: P3
Molecule details ›
Chain: P3
Length: 136 amino acids
Theoretical weight: 14.54 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T1F0 (Residues: 16-151; Coverage: 90%)
Gene name: RPS14
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS19 Chain: Q3
Molecule details ›
Chain: Q3
Length: 129 amino acids
Theoretical weight: 15.12 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U0Q2 (Residues: 12-140; Coverage: 89%)
Gene name: RPS15
Sequence domains: Ribosomal protein S19
Small ribosomal subunit protein uS9 Chain: R3
Molecule details ›
Chain: R3
Length: 142 amino acids
Theoretical weight: 16.03 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SGX4 (Residues: 5-146; Coverage: 97%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein eS17 Chain: S3
Molecule details ›
Chain: S3
Length: 132 amino acids
Theoretical weight: 15.25 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TU13 (Residues: 2-133; Coverage: 98%)
Gene name: RPS17
Sequence domains: Ribosomal S17
Small ribosomal subunit protein uS13 Chain: T3
Molecule details ›
Chain: T3
Length: 144 amino acids
Theoretical weight: 16.9 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TPG3 (Residues: 2-145; Coverage: 95%)
Gene name: RPS18
Sequence domains: Ribosomal protein S13/S18
Small ribosomal subunit protein eS19 Chain: U3
Molecule details ›
Chain: U3
Length: 141 amino acids
Theoretical weight: 15.61 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TN62 (Residues: 3-143; Coverage: 97%)
Gene name: RPS19
Sequence domains: Ribosomal protein S19e
Ribosomal protein S20 Chain: V3
Molecule details ›
Chain: V3
Length: 100 amino acids
Theoretical weight: 11.4 KDa
Source organism: Oryctolagus cuniculus
40S ribosomal protein S21 Chain: W3
Molecule details ›
Chain: W3
Length: 83 amino acids
Theoretical weight: 9.12 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein uS8 Chain: X3
Molecule details ›
Chain: X3
Length: 129 amino acids
Theoretical weight: 14.73 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TG89 (Residues: 2-130; Coverage: 99%)
Gene name: RPS15A
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein uS12 Chain: Y3
Molecule details ›
Chain: Y3
Length: 141 amino acids
Theoretical weight: 15.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ47 (Residues: 2-142; Coverage: 99%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
40S ribosomal protein S24 Chain: Z3
Molecule details ›
Chain: Z3
Length: 124 amino acids
Theoretical weight: 14.43 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T3D8 (Residues: 4-127; Coverage: 95%)
Gene name: RPS24
Sequence domains: Ribosomal protein S24e
Small ribosomal subunit protein eS25 Chain: a3
Molecule details ›
Chain: a3
Length: 75 amino acids
Theoretical weight: 8.53 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TDB3 (Residues: 40-114; Coverage: 61%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
40S ribosomal protein S26 Chain: b3
Molecule details ›
Chain: b3
Length: 101 amino acids
Theoretical weight: 11.65 KDa
Source organism: Oryctolagus cuniculus
Small ribosomal subunit protein eS27 Chain: c3
Molecule details ›
Chain: c3
Length: 83 amino acids
Theoretical weight: 9.35 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TZ76 (Residues: 2-84; Coverage: 99%)
Gene name: RPS27
Sequence domains: Ribosomal protein S27
Small ribosomal subunit protein eS28 Chain: d3
Molecule details ›
Chain: d3
Length: 62 amino acids
Theoretical weight: 7.01 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TIB4 (Residues: 7-68; Coverage: 90%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Small ribosomal subunit protein uS14 Chain: e3
Molecule details ›
Chain: e3
Length: 55 amino acids
Theoretical weight: 6.56 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U7M4 (Residues: 2-56; Coverage: 98%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
Ubiquitin-like domain-containing protein Chain: f3
Molecule details ›
Chain: f3
Length: 57 amino acids
Theoretical weight: 6.51 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: A0A5F9D9G5 (Residues: 354-410; Coverage: 14%)
Sequence domains: Ribosomal protein S30
Small ribosomal subunit protein eS31 Chain: g3
Molecule details ›
Chain: g3
Length: 68 amino acids
Theoretical weight: 7.99 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SK22 (Residues: 83-150; Coverage: 44%)
Gene name: RPS27A
Sequence domains:
Small ribosomal subunit protein RACK1 Chain: h3
Molecule details ›
Chain: h3
Length: 313 amino acids
Theoretical weight: 34.67 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SJB4 (Residues: 2-314; Coverage: 99%)
Gene name: RACK1
Sequence domains: WD domain, G-beta repeat
60S ribosomal protein L8 Chain: j3
Molecule details ›
Chain: j3
Length: 248 amino acids
Theoretical weight: 27 KDa
Source organism: Oryctolagus cuniculus
Large ribosomal subunit protein uL3 Chain: k3
Molecule details ›
Chain: k3
Length: 394 amino acids
Theoretical weight: 45.12 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TL06 (Residues: 2-395; Coverage: 98%)
Gene name: RPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 Chain: l3
Molecule details ›
Chain: l3
Length: 362 amino acids
Theoretical weight: 41.1 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SVW5 (Residues: 2-363; Coverage: 88%)
Gene name: RPL4
Sequence domains:
Large ribosomal subunit protein uL18 Chain: m3
Molecule details ›
Chain: m3
Length: 293 amino acids
Theoretical weight: 34.08 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P19949 (Residues: 3-295; Coverage: 99%)
Gene name: RPL5
Large ribosomal subunit protein eL6 Chain: n3
Molecule details ›
Chain: n3
Length: 251 amino acids
Theoretical weight: 28.82 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SKF7 (Residues: 41-291; Coverage: 86%)
Gene name: RPL6
Sequence domains:
Large ribosomal subunit protein uL30 Chain: o3
Molecule details ›
Chain: o3
Length: 225 amino acids
Theoretical weight: 26.66 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SV32 (Residues: 1-208; Coverage: 100%)
Gene name: RPL7
Sequence domains:
Large ribosomal subunit protein eL8 Chain: p3
Molecule details ›
Chain: p3
Length: 240 amino acids
Theoretical weight: 27.35 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1STW0 (Residues: 80-319; Coverage: 75%)
Gene name: RPL7A
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: q3
Molecule details ›
Chain: q3
Length: 190 amino acids
Theoretical weight: 21.63 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SWI6 (Residues: 1-190; Coverage: 99%)
Gene name: RPL9
Sequence domains: Ribosomal protein L6
Large ribosomal subunit protein uL16 Chain: r3
Molecule details ›
Chain: r3
Length: 213 amino acids
Theoretical weight: 24.51 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: B7NZQ2 (Residues: 2-214; Coverage: 100%)
Gene name: RPL10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: s3
Molecule details ›
Chain: s3
Length: 170 amino acids
Theoretical weight: 19.4 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TUB8 (Residues: 8-177; Coverage: 96%)
Gene name: RPL11
Sequence domains:
Large ribosomal subunit protein eL13 Chain: t3
Molecule details ›
Chain: t3
Length: 210 amino acids
Theoretical weight: 24.2 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1TKB3 (Residues: 2-211; Coverage: 100%)
Gene name: RPL13
Sequence domains: Ribosomal protein L13e
Large ribosomal subunit protein eL14 Chain: u3
Molecule details ›
Chain: u3
Length: 138 amino acids
Theoretical weight: 16.22 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SZ12 (Residues: 2-139; Coverage: 63%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
Messenger RNA Chain: m1
Molecule details ›
Chain: m1
Length: 3 nucleotides
Theoretical weight: 897 Da
P-site tRNA Chain: 21
Molecule details ›
Chain: 21
Length: 76 nucleotides
Theoretical weight: 24.46 KDa
Sequence domains: tRNA
28S ribosomal RNA Chain: A2
Molecule details ›
Chain: A2
Length: 5051 nucleotides
Theoretical weight: 1634.38 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S ribosomal RNA Chain: B2
Molecule details ›
Chain: B2
Length: 119 nucleotides
Theoretical weight: 38.39 KDa
Sequence domains: 5S ribosomal RNA
5.8S ribosomal RNA Chain: C2
Molecule details ›
Chain: C2
Length: 156 nucleotides
Theoretical weight: 50.14 KDa
Sequence domains: 5.8S ribosomal RNA
18S Ribosomal RNA Chain: A3
Molecule details ›
Chain: A3
Length: 1697 nucleotides
Theoretical weight: 547.73 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA

Ligands and Environments

2 bound ligands:
Ligand MG 275 x MG
Ligand ZN 7 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-16052
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017

Quick links

Citations

2 review citations

Structural dynamics in α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor gating.
Gonzalez et al. (2024)
1 more