› 8bhq

Electron Microscopy
3.3Å resolution

GABA-A receptor a5 homomer - a5V3 - RO7172670

Released:
DOI: 10.2210/pdb8bhq/pdb
PDB entry 8bhq coloured by chain, front view.
PDB entry 8bhq coloured by chain, side view.
PDB entry 8bhq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023)
PMID: 37903907
Related structures: EMD-16066

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-aminobutyric acid receptor subunit alpha-5 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 360 amino acids
Theoretical weight: 41.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31644 (Residues: 32-315, 424-450; Coverage: 72%)
Gene name: GABRA5
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 5 x NAG
Ligand QR3 5 x QR3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-16066
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod et al. (2023)