› 8bk5

X-ray diffraction
1.44Å resolution

A structure of the truncated LpMIP with bound inhibitor JK095.

Released:
DOI: 10.2210/pdb8bk5/pdb
PDB entry 8bk5 coloured by chain, front view.
PDB entry 8bk5 coloured by chain, side view.
PDB entry 8bk5 coloured by chain, top view.
Source organism: Legionella pneumophila
Primary publication:
Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding.
Wiedemann C, Whittaker JJ, Carrillo VHP, Goretzki B, Dajka M, Tebbe F, Harder JM, Krajczy PR, Joseph B, Hausch F, Guskov A, Hellmich UA
Int J Biol Macromol 126366 (2023)
PMID: 37633566

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Outer membrane protein MIP Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.35 KDa
Source organism: Legionella pneumophila
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5ZXE0 (Residues: 98-231; Coverage: 63%)
Gene names: lpg0791, mip
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 9QN 1 x 9QN
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3121
Unit cell:
a: 53.54Å b: 53.54Å c: 77.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 0.223
Expression system: Escherichia coli

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