› 8blj

X-ray diffraction
2.18Å resolution

Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1), apo state

Released:
DOI: 10.2210/pdb8blj/pdb
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PDB entry 8blj coloured by chain, front view.
PDB entry 8blj coloured by chain, side view.
PDB entry 8blj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
GluD1 binds GABA and controls inhibitory plasticity.
Piot L, Heroven C, Bossi S, Zamith J, Malinauskas T, Johnson C, Wennagel D, Stroebel D, Charrier C, Aricescu AR, Mony L, Paoletti P
Science eadf3406 (2023)
PMID: 38060673

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, delta-1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 282 amino acids
Theoretical weight: 31.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9ULK0 (Residues: 436-547, 664-823; Coverage: 28%)
Gene names: GRID1, KIAA1220
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand CA 11 x CA
Ligand CL 5 x CL
Ligand NAG 6 x NAG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 86.29Å b: 107.569Å c: 98.559Å
α: 90° β: 94.083° γ: 90°
R-values:
R R work R free
0.208 0.206 0.244
Expression system: Homo sapiens

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Citations

6 citation in other articles

An unexpected role for a glutamate receptor.
Coombs et al. (2023)
5 more

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