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X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor P18

X-ray diffraction
1.55Å resolution
PDB entry 8bol coloured by chain, front view.
PDB entry 8bol coloured by chain, side view.
PDB entry 8bol coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutamate carboxypeptidase 2
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Multimeric state: homo dimer
Accessible surface area: 51280.77 Å2
Buried surface area: 14620.0 Å2
Dissociation area: 2,935.16 Å2
Dissociation energy (ΔGdiss): 11.97 kcal/mol
Dissociation entropy (TΔSdiss): 19.37 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170042

Macromolecules

Glutamate carboxypeptidase 2
Chain: A
Length: 707 amino acids
Theoretical weight: 79.61 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q04609 (Residues: 44-750; Coverage: 94%)
Gene names: FOLH, FOLH1, GIG27, NAALAD1, PSM, PSMA
Pfam:
Glutamate carboxypeptidase 2 in PDB entry 8bol, assembly 1, front view.
Glutamate carboxypeptidase 2 in PDB entry 8bol, assembly 1, side view.
Glutamate carboxypeptidase 2 in PDB entry 8bol, assembly 1, top view.
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