› 8bpv

X-ray diffraction
1.7Å resolution

Crystal structure of JAK2 JH1 in complex with pacritinib

Released:
DOI: 10.2210/pdb8bpv/pdb
PDB entry 8bpv coloured by chain, front view.
PDB entry 8bpv coloured by chain, side view.
PDB entry 8bpv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
Miao Y, Virtanen A, Zmajkovic J, Hilpert M, Skoda RC, Silvennoinen O, Haikarainen T
OpenAccess logo J Med Chem 67 10012-10024 (2024)
PMID: 38843875

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 37.33 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60674 (Residues: 840-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand 6T3 1 x 6T3
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 108.066Å b: 68.959Å c: 49.963Å
α: 90° β: 98.85° γ: 90°
R-values:
R R work R free
0.173 0.172 0.198
Expression system: Trichoplusia ni

Quick links