› 8bq7

X-ray diffraction
2.6Å resolution

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH2829

Released:
DOI: 10.2210/pdb8bq7/pdb
PDB entry 8bq7 coloured by chain, front view.
PDB entry 8bq7 coloured by chain, side view.
PDB entry 8bq7 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Scaletti E, Stenmark P

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-glycosylase/DNA lyase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 318 amino acids
Theoretical weight: 35.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08760 (Residues: 9-325; Coverage: 92%)
Gene name: Ogg1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand R4U 1 x R4U
Ligand NI 1 x NI
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX IV BEAMLINE BioMAX
Spacegroup: P212121
Unit cell:
a: 80.733Å b: 82.095Å c: 169.487Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.255 0.307
Expression system: Escherichia coli

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