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Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K

Source organism: Homo sapiens
Biochemical function: cyclin-dependent protein serine/threonine kinase regulator activity
Biological process: regulation of transcription by RNA polymerase II
Cellular component: nucleus

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EC 2.7.11.23: [RNA-polymerase]-subunit kinase

Reaction catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Systematic name:
ATP:[DNA-directed RNA polymerase] phosphotransferase
Alternative Name(s):
  • CTD kinase
  • STK9

EC 2.7.11.22: Cyclin-dependent kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
  • Bur1
  • Bur1 Cdk
  • CDK
  • Cak1
  • Cak1p
  • Cdc2
  • Cdc2 kinase
  • Cdc28p
  • Cdk-activating kinase
  • Cdk-activating protein kinase
  • Cdk1
  • Cdk2
  • Cdk2
  • Cdk3
  • Cdk4
  • Cdk5
  • Cdk6
  • Cdk7
  • Cdk8
  • Cdk9
  • Cyclin A-activated cdc2
  • Cyclin A-activated cdk2
  • Cyclin D-cdk6 kinase
  • Cyclin D-dependent kinase
  • Cyclin E kinase
  • Cyclin-A associated kinase
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase-2
  • Cyclin-dependent kinase-4
  • Cyclin-dependent protein kinase activating kinase
  • Cyk
  • D-type cyclin kinase
  • Nclk
  • Neuronal cdc2-like kinase
  • PCTAIRE-1
  • STK25

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21797
Domain description: Cyclin-T2-like, C-terminal domain
Occurring in:
  1. Cyclin-K
The deposited structure of PDB entry 8bug contains 3 copies of Pfam domain PF21797 (Cyclin-T2-like, C-terminal domain) in Cyclin-K. Showing 1 copy in chain C.

PF00134
Domain description: Cyclin, N-terminal domain
Occurring in:
  1. Cyclin-K
The deposited structure of PDB entry 8bug contains 3 copies of Pfam domain PF00134 (Cyclin, N-terminal domain) in Cyclin-K. Showing 1 copy in chain C.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 12
The deposited structure of PDB entry 8bug contains 3 copies of Pfam domain PF00069 (Protein kinase domain) in Cyclin-dependent kinase 12. Showing 1 copy in chain B.

PF03178
Domain description: CPSF A subunit region
Occurring in:
  1. DNA damage-binding protein 1
The deposited structure of PDB entry 8bug contains 3 copies of Pfam domain PF03178 (CPSF A subunit region) in DNA damage-binding protein 1. Showing 1 copy in chain D.

PF10433
Domain description: Mono-functional DNA-alkylating methyl methanesulfonate N-term
Occurring in:
  1. DNA damage-binding protein 1
The deposited structure of PDB entry 8bug contains 3 copies of Pfam domain PF10433 (Mono-functional DNA-alkylating methyl methanesulfonate N-term) in DNA damage-binding protein 1. Showing 1 copy in chain D.

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