› 8bwa

X-ray diffraction
3.61Å resolution

Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with platinum

Released:
DOI: 10.2210/pdb8bwa/pdb
PDB entry 8bwa coloured by chain, front view.
PDB entry 8bwa coloured by chain, side view.
PDB entry 8bwa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of BMP signal control by Twisted gastrulation.
Malinauskas T, Moore G, Rudolf AF, Eggington H, Belnoue-Davis HL, El Omari K, Griffiths SC, Woolley RE, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe HL, Siebold C
Nat Commun 15 4976 (2024)
PMID: 38862520

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Twisted gastrulation protein homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZX9 (Residues: 26-223; Coverage: 100%)
Gene names: PSEC0250, TSG, TWSG1
Sequence domains: Twisted gastrulation (Tsg) protein conserved region

Ligands and Environments

1 bound ligand:
Ligand PT 7 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6522
Unit cell:
a: 98.43Å b: 98.43Å c: 188.16Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.342 0.339 0.39
Expression system: Homo sapiens

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